Whether a serum is best used at night depends on its active ingredients and how they work within your skincare routine.
Many treatment serums are well suited to evening use because they support the skin's natural overnight renewal process. Retinol, for example, helps boost skin cell turnover and collagen production while you sleep, when skin is actively repairing and regenerating itself. Retinol is also sensitive to sunlight, making nighttime application the preferred choice.
Not all serums are designed for evening use, however. Antioxidant serums containing ingredients such as vitamin C, resveratrol or ferulic acid that are often better applied in the morning, where they can help defend against oxidative stress caused by UV exposure, pollution and other environmental aggressors throughout the day.
The timing of your serum can also depend on the other active ingredients in your routine. For example, salicylic acid performs best in a more acidic environment, while niacinamide is most effective at a near-neutral pH. Using both at the same time may reduce their optimal performance, so many skincare routines separate them between morning and evening applications.
By using the right serum at the right time, you can help maximise ingredient performance and build a routine that supports both daytime protection and overnight skin renewal.