Niacinamide Serums

• Stage of skincare routine: Apply after cleansing and toning, before moisturiser.
• Time of day: Niacinamide serums are suitable for AM and PM use.

Always follow with broad-spectrum SPF 50+ sun protection in the morning.

Dispense 2 to 3 drops onto fingertips and press into clean, dry skin. Allow full absorption before layering moisturiser. If using a high-concentration vitamin C serum in your routine, allow you vitamin c serum to properly absorb before using niacinamide serums to avoid any potential interaction.

Niacinamide (vitamin B3) is a multifunctional active that inhibits melanin transfer to reduce the appearance of discoloration and dark spots, reinforces the skin barrier, and supports an even skin tone. In Discoloration Defense, it works alongside 3% tranexamic acid and 1% kojic acid to target multiple discoloration pathways simultaneously. In P-TIOX, it complements a peptide complex that signals fibroblasts to reduce the appearance of expression lines.

Niacinamide serums address a broad range of concerns depending on their formulation. SkinCeuticals formulations target hyperpigmentation, post-inflammatory discoloration, and pigment irregulaities, as well as enlarged pores and loss of skin density. Discoloration Defense is specifically formulated for visible dark spots and UV-induced pigmentation. P-TIOX targets dynamic expression lines and declining skin firmness, with niacinamide supporting overall skin clarity within the formula.

Niacinamide strengthens the skin moisture barrier, which reduces transepidermal water loss and supports better moisture retention over time, but it is not a primary hydrating ingredient. For additional moisture, layer with Hydrating B5 Gel before your moisturiser.

With consistent use, SkinCeuticals niacinamide serums deliver measurable reduction in dark spots, post-acne marks, and overall skin tone unevenness. Results are optimised when each serum is used within a complete SkinCeuticals regimen that includes antioxidant protection and daily broad-spectrum SPF.

Choose Discoloration Defense if your primary concern is dark spots, melasma, post-acne pigmentation, or uneven skin tone. Choose P-TIOX if your primary concern is expression lines, loss of firmness, or skin texture with niacinamide enhancing the formula's multi-peptide complex. Both concerns can be addressed concurrently; consult your skincare professional or dermatologist to sequence them correctly within your regimen.

While both are powerful anti-ageing ingredients, they work differently:

• Niacinamide (Vitamin B3) acts at the skin's surface, regulating melanin transfer, strengthening the moisture barrier, reducing redness, and refining texture and pores.
• Peptides are short amino acid chains that penetrate deeper, signalling skin cells to support structural proteins, improve firmness, and reduce dynamic expression lines — as seen in advanced complexes like P-TIOX.



Together, they're highly complementary: niacinamide targets surface clarity while peptides address structural depth — making their combination a comprehensive, multi-target approach to ageing skin.